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jeffnv 18 hours ago [-]
Noticing that the waist circumference on average went down on the peppermint group (85.17 -> 84.61) while the placebo group it went up (88.33 -> 88.65)? Also the resting heart rate dropped for the peppermint group. My initial suspicion is that the peppermint group coincidentally was also the 'got in better shape' group. Maybe the peppermint helped, but for relatively small groups that also seem to be improving waist circumference and heart rates likely due to good diet and exercise, I'm not convinced the peppermint did jack shit. More investigation needed! Would be awesome if it helped though!
vector_spaces 16 hours ago [-]
There has been some research on spearmint suggesting anti-androgen effects in PCOS, which is a bit unexpected to me as I wouldn't expect mint-family herbs to have much hormone modulating effect at all. I would imagine there to be similarities in profile between spearmint and peppermint so perhaps a related mechanism is involved, although I would probably expect the opposite outcome as a naive layperson. But I haven't closely evaluated the paper nor do I know whether there's been much else suggesting this
It is important to remember that herbs are difficult to study in this setting compared with isolated compounds -- likely because their pharmacological and chemical compositions are sensitive to many factors: hour and season of harvest, form consumed (raw powder, alcohol extract, cold water infusion, fat emulsion, hot water infusion, combustion, pyrolysis, essential oil), part consumed (leaf, root, flower, seed), among staggeringly many others. Anyone with experience consuming cannabis or coffee can probably testify to the above
Not to mention that the pharmacologically active compounds in many plants are far from being comprehensively understood, let alone their interactions and dynamics
This isn't to say that every claim about herbs is to be taken seriously. My point here is more that there is no good reason to dismiss the herb itself as a cause yet simply because it's an herb and a fairly mundane one at that. There are easy examples of herbs which have pronounced physiological effects, used for recreation, performance enhancement, as literal poison, to induce labor, to thin the blood -- among others.
So spearmint is not peppermint. Peppermint (mentha pipereta in this study) inhibits CYP3A4 and CYP1A2. CYP1A2 is in the liver and if that is inhibited then estrogen will route down the CYP1B1 path so the ratio of the two metabolites 2-OHE1 v.s 4-OHE1 would be altered. For the PCOS (renamed to PMOS btw) if they start with elevated 2-OHE1 after the peppermint this could result in improve estrogen signaling because the now raised 4-OHE1 has much higher affinity than the 2-OHE1 for ESR1 (Era). ESR1 in particular is known for lowering blood pressure.
This particular path isn't that crazy, but it would only be for a subset of folk. From the study there is something simpler: menthol acts as a natural calcium-channel blocker, triggering vasodilation to reduce blood pressure.
AnthonBerg 4 hours ago [-]
Menthol is wild.
Lightly edited from Wikipedia:
"Menthol's [agonism of] the cold-sensitive Transient Receptor Potential cation channel subfamily M (melastatin) member 8 or TRPM8 receptors is responsible for the well-known cooling sensation it provokes.
Menthol's analgesic properties are mediated through a selective activation of κ-opioid receptors. Menthol blocks calcium channels and voltage-sensitive sodium channels, reducing neural activity that may stimulate muscles.
Some studies show that menthol acts as a GABAᴀ receptor positive allosteric modulator and increases GABAergic transmission in PAG neurons."
…and! Check this out:
"Menthol has anesthetic properties similar to though less potent than propofol, interacting with the same sites on the GABAᴀ receptor."
Propofol. PROPOFOL. The -ol in propofol is the -ol in menthol, haha.
"Menthol may also enhance the activity of glycine receptors and negatively modulate 5-HT3 receptors and nAChRs."
Aaaaand:
"Menthol also lowers blood pressure and antagonizes vasoconstriction through TRPM8 activation."
arthurptj 3 hours ago [-]
many things are wild, just menthol has been studied for the past 50yrs
AnthonBerg 3 hours ago [-]
Well said!!
My point was exactly the hope to indicate how much knowledge there exists. That's the truly wild thing. Or yeah, how unread most of it lays.
ErroneousBosh 4 hours ago [-]
Fuck.
This is what I sound like when I talk about analogue electronics, isn't it?
Thing is I know I could look all those terms up and learn enough to be dangerous in a subject you're clearly very good at.
mrob 16 hours ago [-]
>I wouldn't expect mint-family herbs to have much hormone modulating effect at all
Mints are closely related to pennyroyal (Mentha pulegium), which was traditionally (and dangerously because of toxicity) used as an abortifacient. Its mechanism of action is still unknown, so hormone modulating effects seem plausible to me.
samudrijan 16 hours ago [-]
Sit and drink pennyroyal tea,
I’m anemic royalty.
vector_spaces 14 hours ago [-]
By "mints" I meant the family lamiaceae, so pretty broadly which contains sages, rosemaries, basils, teak, verbena, and in hindsight of course contains examples like this which straddle medicine (depending on dosage and circumstances -- I'm not advocating it be used as such) and poison. Even if just restricting to the genus mentha apparently. Anyway good call
rshm 15 hours ago [-]
Also used as lactation reducing herb.
mapt 2 hours ago [-]
Peppermint is now familiar to most people as the ubiquitous taste of toothpaste, even moreso than candy, food, or drink.
If we cue university student volunteers on Toothpaste -> Selfcare -> Weightloss I wonder what happens.
I also wonder what placebo was used, and to what effect. The typical flavoring agent to make something peppermint-flavored is peppermint essential oil (or cornmint, spearmint, etc), and I don't know how you'd make it convincing without also including a bunch of hypothetically active compounds. The paper lists Schweppes Peppermint Cordial, without mint on the ingredients label. "Peppermint cordial" used as flavoring was historically 10% peppermint oil, and today the Schweppes product they cite just lists "flavourings" as ingredient.
Otterly99 33 minutes ago [-]
It is a 0.7% drop, so very likely to not be significant unfortunately.
ktm5j 17 hours ago [-]
But weight/mass didn't change one bit (okay exaggeration, but not by much), so maybe peppermint helps relieve gas. Who knows? There's a lot that this data could mean, and no simple way to figure it out.
bherms 16 hours ago [-]
i actually had heard it helps w/ bloating/stomach issues online and took for a while and def noticed a debloating effect and less gas... obviously 1 anecdote, but I'd assume any slight waistline reduction is due to that. Also sidenote: pooping often made it feel like I put a breathmint... up... "there" lol
mindhash 8 hours ago [-]
I thought on similar lines. Because I use it often for ibs i noticeably feel much better and I suspect the bp and heart rate reduction could be due to reduced gi effect on body
scorpioxy 10 hours ago [-]
In my culture, that's the goto herbal drink for when you have a stomach ache due to indigestion or gas by the way. I don't know how or why they work but some of these things do work. The footnote here is that it is for pain/discomfort that would also go away by itself if untreated. It just speeds up the process and provides some comfort. For different kinds of pain/discomfort, a doctor needs to be consulted of course.
simondotau 15 hours ago [-]
Not surprising, it’s what happens to capsaicin too. Something has to happen to the molecules/compounds you consume. Either your body discards them, stores them, or transforms them.
The fascinating part is that your anal tissue has that level of sensitivity and insight.
debo_ 14 hours ago [-]
Unlike the anuses in government etc.
wahern 8 hours ago [-]
Mint stimulates release of bile, which can help digestion, especially of fats. I have gallstones and unfortunately recently learned first hand how powerful the effect is after eating a couple of leaves (two kinds, but I forget which) from a neighbor's garden.
I'm wondering if caffeine was accounted for in this. One thing I seem to recall is peppermint tea has some inhibition of CYP1A2. I notice it's missing from the wikipedia page now, so maybe this was a flawed study or something... figured I'd mention in case anyone else knows.
Peppermint oil has traditionally been used in India for digestion, so you may be on to something. I remember this particular brand growing up: https://www.amazon.com/clp/B001NQ7S9G (no relation).
yumraj 12 hours ago [-]
I don’t think that’s peppermint. That’s pudina so spearmint. Mentha spicata.
f33d5173 16 hours ago [-]
Nothing but blood pressure and heart rate was significant, and heart rate only barely so. I wouldn't read anything into the other numbers. It was a 20 day study, you aren't going to get long term outcomes from that.
potatoking 18 hours ago [-]
I'd think weight could be causal for hypertension result or sentiment over health measurement could have been causal for weight or the study could just be too small.
criddell 16 hours ago [-]
When you say weight, do you really mean obesity? And if you are talking about weight, is it likely that people who live in low gravity environments will have fewer hypertension problems?
debo_ 14 hours ago [-]
On the topic of mass, I am certain your pedantic comment will be mass downvoted.
criddell 2 hours ago [-]
I just thought it was interesting to consider how blood pressure might be related to gravity.
d--b 7 hours ago [-]
Yes, and looking at dietary data, the study says that there is no difference in their diets, but carbohydrate intake drop from 217g to 171g. I don’t see how that’s insignificant.
rolisz 18 hours ago [-]
Maybe it helps with weight loss (I wish)
yumraj 18 hours ago [-]
It seems to aid in digestion, soothe upset stomach, so maybe it does.
leni536 14 hours ago [-]
It did help Mr Creosote.
ThePowerOfFuet 14 hours ago [-]
But it was just wafer-thin!
crooked-v 16 hours ago [-]
Wild-ass guess: maybe the aftertaste of peppermint oil twice daily leaves people who are already unhealthy wanting to snack less, leading to minor weight loss.
simondotau 15 hours ago [-]
As a bit of random speculation: improved digestion might reduce the “needy stomach” sensation associated with hunger.
jrflo 15 hours ago [-]
Whenever I see a study like this I assume that the researchers won the p<0.05 lottery
Otterly99 29 minutes ago [-]
Very likely. If they really wanted to make the results a bit stronger, they could at least have switched the two groups after 20 days.
colechristensen 14 hours ago [-]
If you've tried 20 things, you've probably won that lottery. It's an easy lottery to win.
Fun fact: in Soviet Union a common drug which people believe might reduce chance of a heart attack or stroke in high-stress/panic situation was Validol.
What people don't know is that it was just peppermint oil + glucose. I.e. a mint candy in a pill form.
Perhaps it actually did help people just acting as a placebo / distracting from their panic. "I did something now I should get better".
But a concept of a panic attack was not widely known. I guess doctors believed it's easier to prescribe Validol which "prevents heart attack" than to explain people that their panic attack symptoms are caused by their brain
paimapi 13 hours ago [-]
a single RCT of 40 people is about middle-of-the-range when it comes the hierarchy of evidence and is at best a 'that's neat, I'll wait a few years for there to be more studies' if you don't want to do any more thinking about it, a 'I need to see it in context of other studies' if you want a lot of work, or a 'I sure hope there's a meta/review' if you don't have the time but still want to remain skeptical
that said, there is a GRADE-assessed systematic review and meta on mint (PMC11587584) and this linked study's results are 7x the pooled effect size (SBP -8.5mmHg vs -1.2mmHg) of the other RCTs. the review also concludes that more high quality RCTs are needed before anything approaching clinical significance
the wildly disproportionate effect size indicates to me that this is one going to be one of those outlier studies that future reviewers will either likely omit or clearly state that it is an outlier result and if they're super duper honest they'll provide the new pooled results with and without this outlier study
perks_12 37 minutes ago [-]
N=40. No idea why one would release such bullshit.
The worst part will be the idiotic news outlets publishing the stupid headline followed by the pseudoscience peddlers pushing peppermint oil supplements onto an ever-increasing boomer population by AI-generated Instagram ads. Lovely times we live in.
yumraj 19 hours ago [-]
There are two types of peppermint supplements being sold: mentha pipereta that this study looked at, and mentha arvensis.
I wonder if mentha arvensis has the same effect. Supplements vs mint tea would be another interesting thing to study in future.
kzrdude 17 hours ago [-]
Based on your new information, I think it would be good to test the effect of supplemenths vs supplemints.
tclancy 14 hours ago [-]
Please consider the fact there may be children reading before you do something like this again.
trueno 14 hours ago [-]
im bored and want to buy some peppermint sups. someone drop a brand and sell me on it in the marketplace of ideas
drakonka 4 hours ago [-]
I wonder if the benefits could be seen to some extent with peppermint tea as well. I generally drink a cup daily because aside from just being relaxing I find it helps acne or other skin inflammation calm down faster.
amelius 4 hours ago [-]
Maybe because it suppresses/modulates certain hormones? I'd be careful ...
> We performed this study because of major complaints in our area from men about the adverse effects of these herbs on male reproductive function.
drakonka 3 hours ago [-]
I'm not personally concerned with male reproductive function, but have looked into the hormonal effects in women as well. Some have been beneficial when peppermint is ingested in appropriate amounts. Everything in moderation.
_heimdall 10 hours ago [-]
Peppermint is also very helpful for headaches and nausea in my experience. I'll smell some peppermint oil or put a drop on my upper lip, headaches and nausea go away pretty soon after.
I'm guessing that this number is the result of the average of "x" people in the study, and not an individual measurement. But, yeah, I see what that looks like.
1337h4xx 11 hours ago [-]
Essential oils are quite versatile for self-experimentation; maybe one day the world will rediscover oilahuasca.
saulpw 8 hours ago [-]
Maybe we can add some licorice root to balance the effect.
DonHopkins 18 hours ago [-]
Doctor Bronner was right!
Peppermint - Pure-Castile Magic Soap:
Cool, Refresh, and Awaken with Invigorating Peppermint
>Perhaps inspired by that experimental ethos, customers have discovered their own unusual uses in the years since Emanuel started mixing gallons of peppermint castile soap out of his Pershing Square tenement apartment in 1948. [...]
>David, Mike and Lisa Bronner grew up in Glendale, not giving much thought to the prospect of one day taking over the family business and generally regarding their grandfather as a bewildering figure.
>“My granddad was always talking about uniting ‘Spaceship Earth,’ and it was kind of sailing over our heads,” David said.
>“He’d be talking to us as if we were all PhD students in religious studies,” Mike said of visits to Emanuel’s home when the siblings were in elementary school. “He was blind, and every once in a while he would say, ‘Are you there?’ and we’d be like, “All-one, Grandpa!’ And he’d be like, ‘Very good. OK, I want you to recite the peppermint bottle.’”
>The label on the quart size of the Lavender Pure-Castile Magic Soap holds the greatest insight for me into his motivations and goals. The Peppermint label records the tenets of his Moral ABC, his guidelines for humanity to find unity and a path forward. But it is the Lavender quart that hosts his poetry, and in that I see his heart. [...]
>"To keep my health! To do my work! To love, to live!"
>"Great peace is found in little busyness."
>"Work well yourself and work for all."
>"Til we rally, raise, unite!"
>"All-One-God-Faith, All-One! Unite!"
>"Lives of great men all remind us we can make our lives sublime."
>"Life is real! Life is earnest! And the grave is not its goal."
>"Let us then be up and doing ... still achieving, still pursuing"
>"In all we do, let us be generous, fair & loving to Spaceship Earth and all its inhabitants."
>"We're ALL-ONE OR NONE! ALL-ONE!"
NDizzle 13 hours ago [-]
This is my favorite soap, by far, for what it’s worth. The peppermint one, in fact. ALL ONE!
reilly3000 15 hours ago [-]
Aren’t people generally getting some via toothpaste?
simondotau 15 hours ago [-]
But do you spit or swallow?
garbageman 14 hours ago [-]
Whatever you want baby
Havoc 13 hours ago [-]
I need my porch painted and tradesmen are expensive
profsummergig 14 hours ago [-]
So does it therefore reduce stress? Anyone?
Finnucane 11 hours ago [-]
Those old York's Peppermint Patty ads were on to something.
Zylokloto 3 hours ago [-]
Another thing you should do.
How do people even become like 60-70 or 80 around me without all this magic?
tztztzt
Lu2025 15 hours ago [-]
Well, mint tea does make me sleepy
alastairr 18 hours ago [-]
Peppermint group N=20. Mkay. 2 of those lost to followup, one because they didn't like the taste (control group got peppermint cordial). The result might be real but needs followup before we all starting gulping down peppermint oil.
bryceacc 17 hours ago [-]
>50 µL of supplement diluted into 100 mL of water
pretty tiny amount of peppermint was consumed
HeyLaughingBoy 17 hours ago [-]
I was surprised by this too. From a background in writing code to control precision pumps, I have a good idea of what 50 µL looks like and it seemed like an awfully small amount. But I don't know how concentrated the oil is.
FWIW, I had an Indian co-worker who took peppermint oil frequently and said that it was very good for his upset stomach.
jeffbee 17 hours ago [-]
That's enough to turn a whole barrel of water detectably minty.
catigula 16 hours ago [-]
The funny thing is, I've read countless meta-analyses on various mainstream drugs, where total n=hundreds of thousands, and I still don't know if they work at all or not.
Palomides 17 hours ago [-]
HN really upvotes some dumb medical articles, come on, n=20 about peppermint?
now we need a study of adding Peppermint oil into hybiscus tea.
SwellJoe 16 hours ago [-]
A Mediterranean place I used to eat at weekly served a hibiscus mint (spearmint, though) tea. Pretty nice.
cicko 15 hours ago [-]
I'll do a n=1 study on that
rozap 17 hours ago [-]
Silence, we have disruptive direct to consumer peptide startups that need to pump.
ChickeNES 16 hours ago [-]
From PLOS One as well! I remember in college, I was taking a bio class that taught how to read journal articles...and a psych class that was assigning them. Psych class assigned almost solely PLOS One articles...which didn't survive the criticism I was being taught in the bio class lmao
inglor_cz 5 hours ago [-]
Doesn't it make sense to run a small trial before running a big trial?
Also, peppermint oil is unpatentable. Neither Merck nor Novo Nordisk can hope to make billions from it, and without the profit motive, the list of institutions with both the budget and the will to fund a 500+ participant study is pretty short. This might be the best we can get.
And yes, I get that a small trial has less of a value...
pessimizer 16 hours ago [-]
If there's anything consistent about HN as long as I've been on it, it's that HN is orthorexic.
doublepg23 15 hours ago [-]
> orthorexic
New word of the day!
Ylpertnodi 3 hours ago [-]
Nah, been around a while, now.
techteach00 16 hours ago [-]
Also works well for IBS. Popular brand name green box. Bit pricey.
liveoneggs 17 hours ago [-]
herbal tea is good for you, it seems
SwellJoe 16 hours ago [-]
This study did not involve tea. Do you have links to studies showing herbal tea has similar effect? (Sincere question, I drink a lot of peppermint tea for its mild decongestant effects.)
It is important to remember that herbs are difficult to study in this setting compared with isolated compounds -- likely because their pharmacological and chemical compositions are sensitive to many factors: hour and season of harvest, form consumed (raw powder, alcohol extract, cold water infusion, fat emulsion, hot water infusion, combustion, pyrolysis, essential oil), part consumed (leaf, root, flower, seed), among staggeringly many others. Anyone with experience consuming cannabis or coffee can probably testify to the above
Not to mention that the pharmacologically active compounds in many plants are far from being comprehensively understood, let alone their interactions and dynamics
This isn't to say that every claim about herbs is to be taken seriously. My point here is more that there is no good reason to dismiss the herb itself as a cause yet simply because it's an herb and a fairly mundane one at that. There are easy examples of herbs which have pronounced physiological effects, used for recreation, performance enhancement, as literal poison, to induce labor, to thin the blood -- among others.
https://pubmed.ncbi.nlm.nih.gov/19585478/
This particular path isn't that crazy, but it would only be for a subset of folk. From the study there is something simpler: menthol acts as a natural calcium-channel blocker, triggering vasodilation to reduce blood pressure.
Lightly edited from Wikipedia:
"Menthol's [agonism of] the cold-sensitive Transient Receptor Potential cation channel subfamily M (melastatin) member 8 or TRPM8 receptors is responsible for the well-known cooling sensation it provokes.
Menthol's analgesic properties are mediated through a selective activation of κ-opioid receptors. Menthol blocks calcium channels and voltage-sensitive sodium channels, reducing neural activity that may stimulate muscles.
Some studies show that menthol acts as a GABAᴀ receptor positive allosteric modulator and increases GABAergic transmission in PAG neurons."
…and! Check this out:
"Menthol has anesthetic properties similar to though less potent than propofol, interacting with the same sites on the GABAᴀ receptor."
Propofol. PROPOFOL. The -ol in propofol is the -ol in menthol, haha.
"Menthol may also enhance the activity of glycine receptors and negatively modulate 5-HT3 receptors and nAChRs."
Aaaaand:
"Menthol also lowers blood pressure and antagonizes vasoconstriction through TRPM8 activation."
My point was exactly the hope to indicate how much knowledge there exists. That's the truly wild thing. Or yeah, how unread most of it lays.
This is what I sound like when I talk about analogue electronics, isn't it?
Thing is I know I could look all those terms up and learn enough to be dangerous in a subject you're clearly very good at.
Mints are closely related to pennyroyal (Mentha pulegium), which was traditionally (and dangerously because of toxicity) used as an abortifacient. Its mechanism of action is still unknown, so hormone modulating effects seem plausible to me.
If we cue university student volunteers on Toothpaste -> Selfcare -> Weightloss I wonder what happens.
I also wonder what placebo was used, and to what effect. The typical flavoring agent to make something peppermint-flavored is peppermint essential oil (or cornmint, spearmint, etc), and I don't know how you'd make it convincing without also including a bunch of hypothetically active compounds. The paper lists Schweppes Peppermint Cordial, without mint on the ingredients label. "Peppermint cordial" used as flavoring was historically 10% peppermint oil, and today the Schweppes product they cite just lists "flavourings" as ingredient.
The fascinating part is that your anal tissue has that level of sensitivity and insight.
At least this study says the activity was reduced, not significantly though: https://www.sciencedirect.com/science/article/abs/pii/S02786...
What people don't know is that it was just peppermint oil + glucose. I.e. a mint candy in a pill form.
Perhaps it actually did help people just acting as a placebo / distracting from their panic. "I did something now I should get better".
But a concept of a panic attack was not widely known. I guess doctors believed it's easier to prescribe Validol which "prevents heart attack" than to explain people that their panic attack symptoms are caused by their brain
that said, there is a GRADE-assessed systematic review and meta on mint (PMC11587584) and this linked study's results are 7x the pooled effect size (SBP -8.5mmHg vs -1.2mmHg) of the other RCTs. the review also concludes that more high quality RCTs are needed before anything approaching clinical significance
the wildly disproportionate effect size indicates to me that this is one going to be one of those outlier studies that future reviewers will either likely omit or clearly state that it is an outlier result and if they're super duper honest they'll provide the new pooled results with and without this outlier study
The worst part will be the idiotic news outlets publishing the stupid headline followed by the pseudoscience peddlers pushing peppermint oil supplements onto an ever-increasing boomer population by AI-generated Instagram ads. Lovely times we live in.
I wonder if mentha arvensis has the same effect. Supplements vs mint tea would be another interesting thing to study in future.
https://www.sciencedirect.com/science/article/pii/S009042950...
> We performed this study because of major complaints in our area from men about the adverse effects of these herbs on male reproductive function.
Peppermint - Pure-Castile Magic Soap: Cool, Refresh, and Awaken with Invigorating Peppermint
https://www.drbronner.com/products/peppermint-pure-castile-l...
Dr. Bronner invented the peppermint oil soap for soiled diapers
https://www.sandiegoreader.com/news/1978/nov/02/cover-look-f...
Created in California: How Dr. Bronner’s became the soap for every subculture
https://www.latimes.com/business/story/2023-07-12/dr-bronner...
>Perhaps inspired by that experimental ethos, customers have discovered their own unusual uses in the years since Emanuel started mixing gallons of peppermint castile soap out of his Pershing Square tenement apartment in 1948. [...]
>David, Mike and Lisa Bronner grew up in Glendale, not giving much thought to the prospect of one day taking over the family business and generally regarding their grandfather as a bewildering figure.
>“My granddad was always talking about uniting ‘Spaceship Earth,’ and it was kind of sailing over our heads,” David said.
>“He’d be talking to us as if we were all PhD students in religious studies,” Mike said of visits to Emanuel’s home when the siblings were in elementary school. “He was blind, and every once in a while he would say, ‘Are you there?’ and we’d be like, “All-one, Grandpa!’ And he’d be like, ‘Very good. OK, I want you to recite the peppermint bottle.’”
Lisa Bronner: The Poetry of the Lavender Label
https://www.lisabronner.com/the-poetry-of-the-lavender-label
>The label on the quart size of the Lavender Pure-Castile Magic Soap holds the greatest insight for me into his motivations and goals. The Peppermint label records the tenets of his Moral ABC, his guidelines for humanity to find unity and a path forward. But it is the Lavender quart that hosts his poetry, and in that I see his heart. [...]
>"To keep my health! To do my work! To love, to live!"
>"Great peace is found in little busyness."
>"Work well yourself and work for all."
>"Til we rally, raise, unite!"
>"All-One-God-Faith, All-One! Unite!"
>"Lives of great men all remind us we can make our lives sublime."
>"Life is real! Life is earnest! And the grave is not its goal."
>"Let us then be up and doing ... still achieving, still pursuing"
>"In all we do, let us be generous, fair & loving to Spaceship Earth and all its inhabitants."
>"We're ALL-ONE OR NONE! ALL-ONE!"
How do people even become like 60-70 or 80 around me without all this magic?
tztztzt
pretty tiny amount of peppermint was consumed
FWIW, I had an Indian co-worker who took peppermint oil frequently and said that it was very good for his upset stomach.
Also, peppermint oil is unpatentable. Neither Merck nor Novo Nordisk can hope to make billions from it, and without the profit motive, the list of institutions with both the budget and the will to fund a 500+ participant study is pretty short. This might be the best we can get.
And yes, I get that a small trial has less of a value...
New word of the day!